Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:activatedBy |
gptkb:caspase-1
|
| gptkbp:associatedWith |
sepsis
autoimmune diseases gout rheumatoid arthritis |
| gptkbp:discoveredBy |
Charles A. Dinarello
|
| gptkbp:encodedBy |
IL1B gene
|
| gptkbp:Entrez_Gene_ID |
3553
|
| gptkbp:function |
mediates inflammatory response
induces fever promotes leukocyte infiltration stimulates production of acute-phase proteins |
| https://www.w3.org/2000/01/rdf-schema#label |
IL-1 beta
|
| gptkbp:inhibitedBy |
gptkb:canakinumab
gptkb:anakinra rilonacept |
| gptkbp:locatedOnChromosome |
2q14
|
| gptkbp:memberOf |
interleukin-1 family
|
| gptkbp:molecularWeight |
17 kDa
|
| gptkbp:predecessor |
pro-IL-1 beta
|
| gptkbp:producedBy |
activated macrophages
|
| gptkbp:recipient |
IL-1 receptor type I
IL-1 receptor type II |
| gptkbp:role |
innate immunity
chronic inflammation |
| gptkbp:secretes |
dendritic cells
monocytes |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
single polypeptide chain
|
| gptkbp:UniProtID |
P01584
|
| gptkbp:bfsParent |
gptkb:Ccl2
gptkb:P03951 |
| gptkbp:bfsLayer |
8
|