Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Dupilumab
gptkb:dupilumab |
| gptkbp:associated_with |
gptkb:asthma
allergic responses |
| gptkbp:composed_of |
gptkb:IL-13_Rα1
gptkb:IL-13_Rα2 |
| gptkbp:established |
Th2 cell differentiation
|
| gptkbp:function |
binds interleukin-13
|
| gptkbp:has_member |
gptkb:IL-4_Rα
|
| gptkbp:has_role |
fibrosis
tissue remodeling |
| https://www.w3.org/2000/01/rdf-schema#label |
IL-13 receptor
|
| gptkbp:influence |
cell signaling pathways
|
| gptkbp:influences |
cytokine production
|
| gptkbp:interacts_with |
gptkb:IL-4
|
| gptkbp:is_associated_with |
eosinophilia
|
| gptkbp:is_involved_in |
gptkb:chronic_obstructive_pulmonary_disease_(COPD)
gptkb:Company gptkb:psychologist immune response metabolic disorders autoimmune diseases chronic pain obesity neuroinflammation cardiovascular diseases fungal infections infectious diseases tumor microenvironment inflammatory responses pulmonary fibrosis cancer progression chronic inflammation viral infections bacterial infections atopic dermatitis pulmonary diseases gastrointestinal disorders interstitial lung disease immune evasion parasitic infections skin inflammation chronic rhinosinusitis mucus production airway hyperresponsiveness lung remodeling |
| gptkbp:is_part_of |
IL-13 signaling pathway
|
| gptkbp:is_represented_in |
gptkb:T_cells
B cells fibroblasts macrophages epithelial cells smooth muscle cells |
| gptkbp:located_in |
cell membrane
|
| gptkbp:regulates |
gene expression
|
| gptkbp:targets |
therapeutic antibodies
|