Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alsoKnownAs |
gptkb:CD275
gptkb:B7-H2 B7RP-1 |
| gptkbp:binds |
gptkb:ICOS
|
| gptkbp:discoveredBy |
Yoshinaga et al.
|
| gptkbp:encodedBy |
ICOSLG gene
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000160179
23308 |
| gptkbp:expressedIn |
gptkb:B_cells
dendritic cells monocytes antigen-presenting cells |
| gptkbp:firstDescribed |
2000
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
costimulatory molecule
regulation of T cell activation |
| gptkbp:HGNC_ID |
HGNC:19100
|
| https://www.w3.org/2000/01/rdf-schema#label |
ICOS ligand
|
| gptkbp:involvedIn |
immune response
T cell proliferation cytokine secretion |
| gptkbp:locatedOnChromosome |
chromosome 21q22.3
|
| gptkbp:memberOf |
gptkb:B7_family
|
| gptkbp:molecularWeight |
~34 kDa
|
| gptkbp:OMIM |
604558
|
| gptkbp:relatedTo |
immunotherapy
autoimmune diseases |
| gptkbp:structure |
type I transmembrane protein
|
| gptkbp:UniProtID |
Q9H7M9
|
| gptkbp:bfsParent |
gptkb:CD275
|
| gptkbp:bfsLayer |
8
|