Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
heat shock protein |
| gptkbp:alternativeName |
gptkb:HSPA
DnaK (in bacteria) Heat shock 70 kDa protein |
| gptkbp:associatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases |
| gptkbp:binds |
gptkb:ATP
gptkb:ADP unfolded proteins |
| gptkbp:conservedIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:encodedBy |
gptkb:HSPA1A_gene
gptkb:HSPA1B_gene gptkb:HSPA1L_gene |
| gptkbp:foundIn |
gptkb:endoplasmic_reticulum
gptkb:nucleus mitochondria cytosol |
| gptkbp:function |
protein folding
prevention of protein aggregation chaperone activity assists in protein refolding |
| https://www.w3.org/2000/01/rdf-schema#label |
Hsp70 protein
|
| gptkbp:inducedBy |
heat shock
cellular stress |
| gptkbp:interactsWith |
co-chaperones
Hsp40 protein |
| gptkbp:involvedIn |
apoptosis regulation
cellular stress response antigen presentation protein translocation protein homeostasis |
| gptkbp:molecularWeight |
70 kDa
|
| gptkbp:orthologIn |
BiP (HSPA5)
DnaK (Escherichia coli) mtHsp70 (HSPA9) |
| gptkbp:regulates |
cell survival
protein quality control |
| gptkbp:structure |
C-terminal domain
N-terminal ATPase domain substrate-binding domain |
| gptkbp:target |
drug development
|
| gptkbp:usedIn |
gptkb:biotechnology
molecular biology research |
| gptkbp:bfsParent |
gptkb:HSPA1B
|
| gptkbp:bfsLayer |
8
|