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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:NKX2-5
gptkb:CSX
gptkb:NKX2E
NKX2-5 cardiac-specific homeobox
|
|
gptkbp:associatedWith
|
congenital heart disease
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
homeobox domain
|
|
gptkbp:encodedBy
|
NKX2-5 gene
|
|
gptkbp:Entrez_Gene_ID
|
1482
|
|
gptkbp:expressedIn
|
embryonic development
heart
|
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
transcription factor
cardiac development
|
|
gptkbp:HGNC_ID
|
7837
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Homeobox protein Nkx-2.5
|
|
gptkbp:interactsWith
|
gptkb:SRF
gptkb:GATA4
gptkb:TBX5
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q35
|
|
gptkbp:molecularWeight
|
35 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:atrial_septal_defect
gptkb:tetralogy_of_Fallot
conduction defects
|
|
gptkbp:OMIM
|
600584
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:PDB
|
1V4Z
|
|
gptkbp:regulates
|
cardiac conduction system
cardiac morphogenesis
cardiac progenitor cell fate
ventricular development
ANF gene
cardiac-specific genes
cardiac septation
cardiac muscle cell differentiation
|
|
gptkbp:sequence
|
324 amino acids
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
Q9H2X6
|
|
gptkbp:bfsParent
|
gptkb:NKX2-5
|
|
gptkbp:bfsLayer
|
7
|