|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:associatedWith
|
gptkb:cancer
immune disorders
|
|
gptkbp:class
|
class IV histone deacetylase
|
|
gptkbp:discoveredBy
|
2002
|
|
gptkbp:encodedBy
|
gptkb:HDAC11_gene
|
|
gptkbp:Entrez_Gene_ID
|
79885
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.5.1.98
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
gptkb:thymus
brain
heart
liver
spleen
colon
pancreas
peripheral blood leukocytes
|
|
gptkbp:family
|
histone deacetylase family
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
removes acetyl groups from lysine residues on histone proteins
|
|
gptkbp:gene
|
gptkb:HDAC11
|
|
gptkbp:GO_function
|
histone deacetylase activity
|
|
gptkbp:GOProcess
|
chromatin modification
regulation of transcription
negative regulation of gene expression
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histone deacetylase 11
|
|
gptkbp:inhibitedBy
|
SAHA (Vorinostat)
Trichostatin A
|
|
gptkbp:involves
|
epigenetic regulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3p25
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:OMIM
|
607003
|
|
gptkbp:orthologInMouse
|
Hdac11
|
|
gptkbp:pathway
|
epigenetic regulation of gene expression
|
|
gptkbp:PDB
|
2NYG
|
|
gptkbp:RefSeq
|
NM_024827
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:UniProtID
|
gptkb:Q96DB2
|
|
gptkbp:bfsParent
|
gptkb:HDAC11
|
|
gptkbp:bfsLayer
|
8
|