Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:HK
sensor kinase |
| gptkbp:compatibleWith |
animals
|
| gptkbp:discoveredBy |
J. Adler
|
| gptkbp:discoveredIn |
1967
|
| gptkbp:domain |
HATPase_c domain
HisKA domain |
| gptkbp:enzymeCommissionNumber |
EC 2.7.13.3
|
| gptkbp:foundIn |
gptkb:Bacteria
plants archaea |
| gptkbp:function |
catalyzes the transfer of a phosphate group to a histidine residue
|
| gptkbp:GO_term |
GO:0000155
|
| https://www.w3.org/2000/01/rdf-schema#label |
Histidine kinase
|
| gptkbp:inhibitedBy |
closantel
waldiomycin |
| gptkbp:involves |
two-component signal transduction system
|
| gptkbp:mechanismOfAction |
autophosphorylation
phosphotransfer |
| gptkbp:notableAbsence |
mammals
|
| gptkbp:PDB |
1B3Q
|
| gptkbp:phosphorylates |
conserved histidine
histidine residue |
| gptkbp:presentIn |
prokaryotes
some lower eukaryotes |
| gptkbp:product |
gptkb:ADP
protein N-phospho-L-histidine |
| gptkbp:regulates |
response regulator proteins
|
| gptkbp:requires |
osmoregulation
bacterial chemotaxis virulence in some pathogens |
| gptkbp:structure |
homodimer
|
| gptkbp:substrate |
gptkb:ATP
protein L-histidine |
| gptkbp:target |
antimicrobial drug development
|
| gptkbp:UniProtID |
gptkb:cell_membrane
gptkb:Cytoplasm gptkb:Signal_transduction gptkb:Transferase Kinase ATP-binding Phosphoprotein Autophosphorylation Two-component regulatory system Nucleotide-binding Transmembrane |
| gptkbp:bfsParent |
gptkb:EC_2.7.11.31
gptkb:histidine_kinase gptkb:protein-histidine_kinase |
| gptkbp:bfsLayer |
8
|