|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:ATP:hexose_6-phosphotransferase
gptkb:D-hexokinase
|
|
gptkbp:biologicalProcess
|
transferase activity
|
|
gptkbp:CASNumber
|
9001-51-8
|
|
gptkbp:catalyzes
|
phosphorylation of glucose
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:discoveredBy
|
gptkb:Otto_Meyerhof
|
|
gptkbp:discoveredIn
|
1927
|
|
gptkbp:EC_number
|
2.7.1.1
|
|
gptkbp:enzymeClassification
|
transferase
|
|
gptkbp:expressedIn
|
all tissues (HK1)
liver (HK4/glucokinase)
muscle (HK2)
|
|
gptkbp:family
|
hexokinase family
|
|
gptkbp:foundIn
|
gptkb:yeast
gptkb:Bacteria
human cells
most organisms
|
|
gptkbp:gene
|
gptkb:HK1
gptkb:HK2
gptkb:HK3
gptkb:HK4
|
|
gptkbp:gene_location_(HK1)
|
chromosome 10q22
|
|
gptkbp:gene_location_(HK2)
|
chromosome 2p13
|
|
gptkbp:gene_location_(HK3)
|
chromosome 5q35
|
|
gptkbp:gene_location_(HK4)
|
chromosome 7p15.3
|
|
gptkbp:GO_term
|
gptkb:GO:0004396
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hexokinase
|
|
gptkbp:importantFor
|
first step of glycolysis
|
|
gptkbp:inhibitedBy
|
gptkb:N-acetylglucosamine
gptkb:glucose-6-phosphate
2-deoxyglucose
|
|
gptkbp:KEGG_pathway
|
hsa00010
|
|
gptkbp:locale
|
gptkb:cytoplasm
outer mitochondrial membrane
|
|
gptkbp:molecularWeight
|
~100 kDa (human HK1)
|
|
gptkbp:optimum_pH
|
7.5
37°C
|
|
gptkbp:pathway
|
glycolysis
|
|
gptkbp:PDB
|
gptkb:1HKB
|
|
gptkbp:product
|
gptkb:ADP
gptkb:glucose-6-phosphate
|
|
gptkbp:related_enzyme
|
gptkb:glucokinase
|
|
gptkbp:significance
|
deficiency causes hemolytic anemia
|
|
gptkbp:structure
|
monomeric or dimeric
|
|
gptkbp:substrate
|
gptkb:ATP
glucose
|
|
gptkbp:UniProt_ID_(human_HK1)
|
P19367
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|