|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
glucose
fructose-1-phosphate
|
|
gptkbp:activity_measured_by
|
glucose phosphorylation rate
|
|
gptkbp:alternativeName
|
gptkb:hexokinase_D
hexokinase IV
|
|
gptkbp:catalyzes
|
phosphorylation of glucose to glucose-6-phosphate
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:discoveredBy
|
gptkb:Bernhard_Tollens
|
|
gptkbp:discoveredIn
|
1902
|
|
gptkbp:EC_number
|
2.7.1.2
|
|
gptkbp:expressedIn
|
gptkb:human
gptkb:mouse
right
pancreas
kidney (minor)
brain (minor)
gut (minor)
|
|
gptkbp:foundIn
|
liver
pancreatic beta cells
|
|
gptkbp:gene
|
gptkb:GCK
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glucokinase
|
|
gptkbp:inhibitedBy
|
fructose-6-phosphate
glucokinase regulatory protein
|
|
gptkbp:Km_for_glucose
|
high
|
|
gptkbp:locatedOnChromosome
|
7p13
|
|
gptkbp:molecularWeight
|
~50 kDa
|
|
gptkbp:mutationAssociatedWith
|
gain-of-function
loss-of-function
maturity onset diabetes of the young type 2 (MODY2)
|
|
gptkbp:not_inhibited_by
|
gptkb:glucose-6-phosphate
|
|
gptkbp:OMIM
|
138079
|
|
gptkbp:PDB
|
1V4S
|
|
gptkbp:product
|
gptkb:ADP
gptkb:glucose-6-phosphate
|
|
gptkbp:proteinFamily
|
transferase
|
|
gptkbp:regulates
|
regulated by glucose concentration
regulated by glucokinase regulatory protein
|
|
gptkbp:role
|
glycolysis
glucose homeostasis
|
|
gptkbp:significance
|
gptkb:diabetes_mellitus
gptkb:hyperinsulinemic_hypoglycemia
|
|
gptkbp:structure
|
monomeric
|
|
gptkbp:substrate
|
gptkb:ATP
glucose
|
|
gptkbp:systematicName
|
gptkb:ATP:D-glucose_6-phosphotransferase
|
|
gptkbp:UniProtID
|
gptkb:P35557
|
|
gptkbp:bfsParent
|
gptkb:Hexokinase
gptkb:HK4
gptkb:glucose-6-phosphate
gptkb:hexokinase_IV_(glucokinase)
gptkb:CHEBI:15765
|
|
gptkbp:bfsLayer
|
7
|