Hereditary nonpolyposis colorectal cancer
GPTKB entity
Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
syndrome |
| gptkbp:affects |
colon
rectum |
| gptkbp:alsoKnownAs |
gptkb:Lynch_syndrome
|
| gptkbp:category |
colorectal cancer
genetic disorder hereditary cancer syndrome |
| gptkbp:diagnosedBy |
genetic testing
microsatellite instability testing |
| gptkbp:firstDescribed |
gptkb:Henry_T._Lynch
|
| https://www.w3.org/2000/01/rdf-schema#label |
Hereditary nonpolyposis colorectal cancer
|
| gptkbp:inheritance |
autosomal dominant
|
| gptkbp:MeSH_ID |
D015179
|
| gptkbp:mutationAssociatedWith |
gptkb:MLH1
gptkb:MSH2 gptkb:MSH6 gptkb:PMS2 gptkb:EPCAM |
| gptkbp:OMIM |
120435
|
| gptkbp:prevalence |
2-4% of all colorectal cancers
|
| gptkbp:riskFactor |
gptkb:cancer
gptkb:endometrial_cancer colorectal cancer pancreatic cancer stomach cancer small intestine cancer urinary tract cancer |
| gptkbp:symptom |
family history of cancer
early-onset colorectal cancer |
| gptkbp:treatment |
surgery
chemotherapy regular screening |
| gptkbp:bfsParent |
gptkb:Inherited_Cancer_Syndromes
|
| gptkbp:bfsLayer |
7
|