Hereditary Non-Polyposis Colorectal Cancer

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf genetic disorder
syndrome
gptkbp:affects colon
rectum
gptkbp:alsoKnownAs gptkb:Lynch_syndrome
gptkb:HNPCC
gptkbp:category colorectal cancer
genetic disorder
hereditary cancer syndrome
gptkbp:characterizedBy gptkb:early_onset_colorectal_cancer
absence of numerous polyps
gptkbp:diagnosedBy gptkb:Amsterdam_criteria
gptkb:Bethesda_guidelines
genetic testing
gptkbp:firstDescribed gptkb:Henry_T._Lynch
https://www.w3.org/2000/01/rdf-schema#label Hereditary Non-Polyposis Colorectal Cancer
gptkbp:inheritance autosomal dominant
gptkbp:mutationAssociatedWith gptkb:MLH1
gptkb:MSH2
gptkb:MSH6
gptkb:PMS2
gptkb:EPCAM
gptkbp:prevalence 2-4% of all colorectal cancers
gptkbp:riskFactor gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
gastric cancer
urinary tract cancer
gptkbp:treatment surgery
chemotherapy
regular screening
gptkbp:bfsParent gptkb:HNPCR
gptkbp:bfsLayer 7