Hereditary Non-Polyposis Colorectal Cancer
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:syndrome
gptkb:genetic_disorder |
| gptkbp:affects |
colon
rectum |
| gptkbp:alsoKnownAs |
gptkb:Lynch_syndrome
gptkb:HNPCC |
| gptkbp:category |
gptkb:genetic_disorder
gptkb:hereditary_cancer_syndrome colorectal cancer |
| gptkbp:characterizedBy |
gptkb:early_onset_colorectal_cancer
absence of numerous polyps |
| gptkbp:diagnosedBy |
gptkb:Amsterdam_criteria
gptkb:Bethesda_guidelines genetic testing |
| gptkbp:firstDescribed |
gptkb:Henry_T._Lynch
|
| gptkbp:inheritance |
autosomal dominant
|
| gptkbp:mutationAssociatedWith |
gptkb:MLH1
gptkb:MSH2 gptkb:MSH6 gptkb:PMS2 gptkb:EPCAM |
| gptkbp:prevalence |
2-4% of all colorectal cancers
|
| gptkbp:riskFactor |
gptkb:cancer
gptkb:endometrial_cancer colorectal cancer gastric cancer urinary tract cancer |
| gptkbp:treatment |
surgery
chemotherapy regular screening |
| gptkbp:bfsParent |
gptkb:HNPCR
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
Hereditary Non-Polyposis Colorectal Cancer
|