HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR

URI: https://gptkb.org/entity/HUMAN_UROKINASE-TYPE_PLASMINOGEN_ACTIVATOR
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:uPA
gptkbp:associatedWith cancer metastasis
gptkbp:cleavage plasmin
gptkbp:clinicalTrialPhase used in myocardial infarction
used in pulmonary embolism
gptkbp:discoveredBy Mid-20th century researchers
gptkbp:EC_number 3.4.21.73
gptkbp:expressedIn macrophages
endothelial cells
kidney cells
gptkbp:function converts plasminogen to plasmin
gptkbp:gene gptkb:PLAU
https://www.w3.org/2000/01/rdf-schema#label HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR
gptkbp:inhibitedBy gptkb:PAI-1
PAI-2
gptkbp:involvedIn cell migration
fibrinolysis
tissue remodeling
gptkbp:locatedOnChromosome gptkb:10q22.2
gptkbp:location extracellular space
gptkbp:medicalUse thrombolytic therapy
gptkbp:molecularWeight 54 kDa
gptkbp:OMIM 191840
gptkbp:PDB 1OWE
gptkbp:recipient uPAR
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure gptkb:serine_protease
gptkbp:substrate gptkb:plasminogen
gptkbp:UniProtID gptkb:P00749
gptkbp:bfsParent gptkb:1HUR
gptkbp:bfsLayer 7