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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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HMGs
high mobility group proteins
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gptkbp:contains
|
HMG-box domain
|
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gptkbp:database
|
GeneCards: HMG family
HGNC: 4972 (HMGB1)
UniProt: P09429 (HMGB1)
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gptkbp:discoveredBy
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gptkb:Lennart_Philipson
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gptkbp:firstDescribed
|
1973
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gptkbp:foundIn
|
eukaryotes
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gptkbp:fullName
|
High Mobility Group proteins
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gptkbp:function
|
bind DNA
regulate transcription
modulate chromatin structure
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gptkbp:GO_term
|
GO:0003682
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gptkbp:interactsWith
|
gptkb:nucleosomes
transcription factors
histones
|
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gptkbp:location
|
gptkb:nucleus
|
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gptkbp:molecularWeight
|
10-30 kDa
|
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gptkbp:notableMember
|
gptkb:HMGB1
gptkb:HMGN1
HMGA1
|
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gptkbp:relatedTo
|
gptkb:immune_response
gene expression regulation
developmental processes
chromatin remodeling
DNA bending
|
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gptkbp:role
|
gptkb:V(D)J_recombination
apoptosis
cell differentiation
DNA repair
cancer progression
inflammation
|
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gptkbp:significance
|
biomarker for cancer
autoimmune disease marker
|
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gptkbp:structure
|
HMG-box domain
acidic C-terminal tail
AT-hook motif
|
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gptkbp:subclassOf
|
gptkb:non-histone_chromosomal_proteins
|
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gptkbp:subfamily
|
HMGA
HMGB
HMGN
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gptkbp:bfsParent
|
gptkb:high-mobility_group_proteins
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gptkbp:bfsLayer
|
8
|
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https://www.w3.org/2000/01/rdf-schema#label
|
HMG proteins
|