Statements (46)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
HMGs
high mobility group proteins |
| gptkbp:contains |
HMG-box domain
|
| gptkbp:database |
GeneCards: HMG family
HGNC: 4972 (HMGB1) UniProt: P09429 (HMGB1) |
| gptkbp:discoveredBy |
gptkb:Lennart_Philipson
|
| gptkbp:firstDescribed |
1973
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:fullName |
High Mobility Group proteins
|
| gptkbp:function |
bind DNA
regulate transcription modulate chromatin structure |
| gptkbp:GO_term |
GO:0003682
|
| https://www.w3.org/2000/01/rdf-schema#label |
HMG proteins
|
| gptkbp:interactsWith |
gptkb:nucleosomes
transcription factors histones |
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:molecularWeight |
10-30 kDa
|
| gptkbp:notableMember |
gptkb:HMGB1
gptkb:HMGN1 HMGA1 |
| gptkbp:relatedTo |
immune response
gene expression regulation developmental processes chromatin remodeling DNA bending |
| gptkbp:role |
gptkb:V(D)J_recombination
apoptosis cell differentiation DNA repair cancer progression inflammation |
| gptkbp:significance |
biomarker for cancer
autoimmune disease marker |
| gptkbp:structure |
HMG-box domain
acidic C-terminal tail AT-hook motif |
| gptkbp:subclassOf |
gptkb:non-histone_chromosomal_proteins
|
| gptkbp:subfamily |
HMGA
HMGB HMGN |
| gptkbp:bfsParent |
gptkb:high-mobility_group_proteins
|
| gptkbp:bfsLayer |
8
|