|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
multiple isoforms
|
|
gptkbp:associatedWith
|
autoimmune diseases
viral infections
pre-eclampsia
|
|
gptkbp:cellSurfaceExpression
|
low
|
|
gptkbp:encodedBy
|
HLA-G gene
|
|
gptkbp:Entrez_Gene_ID
|
3135
|
|
gptkbp:expressedIn
|
gptkb:placenta
fetal tissues
some tumors
|
|
gptkbp:foundIn
|
humans
|
|
gptkbp:function
|
immune tolerance
inhibition of T cell responses
inhibition of natural killer cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HLA-G protein
|
|
gptkbp:immunosuppressive
|
yes
|
|
gptkbp:ligand
|
gptkb:LILRB1
gptkb:LILRB2
KIR2DL4
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
|
gptkbp:memberOf
|
gptkb:MHC_class_I_family
|
|
gptkbp:molecularWeight
|
~39 kDa
|
|
gptkbp:OMIM
|
142871
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:role
|
cancer immune evasion
transplantation tolerance
maternal-fetal tolerance
|
|
gptkbp:solubleForm
|
yes
|
|
gptkbp:structure
|
heterodimer with beta-2 microglobulin
|
|
gptkbp:UniProtID
|
gptkb:P17693
|
|
gptkbp:bfsParent
|
gptkb:HLAG
gptkb:HLA-G
|
|
gptkbp:bfsLayer
|
8
|