Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
DDE motif
|
| gptkbp:catalyzes |
DNA strand transfer
|
| gptkbp:cofactor |
Mg2+
Mn2+ |
| gptkbp:EC_number |
2.7.7.49
|
| gptkbp:encodedBy |
gptkb:pol_gene
|
| gptkbp:foundIn |
gptkb:HIV-2
|
| gptkbp:function |
integration of viral DNA into host genome
|
| gptkbp:gene |
IN
|
| https://www.w3.org/2000/01/rdf-schema#label |
HIV-2 integrase
|
| gptkbp:inhibitedBy |
gptkb:dolutegravir
gptkb:elvitegravir gptkb:raltegravir |
| gptkbp:length |
approximately 288 amino acids
|
| gptkbp:molecularWeight |
approximately 32 kDa
|
| gptkbp:presentIn |
HIV-2 virion
|
| gptkbp:requires |
HIV-2 replication
|
| gptkbp:sequence_similarity |
gptkb:HIV-1_integrase
|
| gptkbp:structure |
three domains: N-terminal, catalytic core, C-terminal
|
| gptkbp:target |
gptkb:integrase_inhibitors
|
| gptkbp:bfsParent |
gptkb:Integrase_Strand_Transfer_Inhibitors
|
| gptkbp:bfsLayer |
6
|