|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:C-terminal_domain
|
DNA binding
|
|
gptkbp:catalytic_core_domain
|
contains DDE motif
|
|
gptkbp:cofactor
|
Mg2+
Mn2+
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:EC_number
|
2.7.7.49
|
|
gptkbp:encodedBy
|
gptkb:pol_gene
|
|
gptkbp:foundIn
|
gptkb:HIV-1
|
|
gptkbp:function
|
integration of viral DNA into host genome
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIV-1 integrase
|
|
gptkbp:inhibitedBy
|
gptkb:dolutegravir
gptkb:elvitegravir
gptkb:raltegravir
bictegravir
|
|
gptkbp:length
|
288 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:HIV-1_genome
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:N-terminal_domain
|
zinc-binding
|
|
gptkbp:organism
|
gptkb:Human_immunodeficiency_virus_type_1
|
|
gptkbp:PDB
|
gptkb:1EX4
|
|
gptkbp:requires
|
HIV replication
|
|
gptkbp:role_in_life_cycle
|
integration of proviral DNA
|
|
gptkbp:structure
|
three domains
|
|
gptkbp:target
|
integrase strand transfer inhibitors
|
|
gptkbp:targetOfDrug
|
antiretroviral therapy
|
|
gptkbp:UniProtID
|
P12497
|
|
gptkbp:bfsParent
|
gptkb:Integrase_Strand_Transfer_Inhibitors
|
|
gptkbp:bfsLayer
|
6
|