Integrase Strand Transfer Inhibitors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	antiretroviral drug class
gptkbp:abbreviation	gptkb:INSTIs
gptkbp:approvalYear	2007
gptkbp:approvedBy	gptkb:FDA
gptkbp:availableOn	global
gptkbp:category	antiviral drugs HIV integrase inhibitors HIV/AIDS drugs
gptkbp:combinationTherapy	often used with NNRTIs often used with NRTIs often used with protease inhibitors
gptkbp:contraindication	hypersensitivity to drug
gptkbp:cost	varies by region and drug
gptkbp:discoveredBy	gptkb:Merck_(raltegravir)
gptkbp:drugClass	gptkb:cabotegravir gptkb:dolutegravir gptkb:elvitegravir gptkb:raltegravir bictegravir
gptkbp:drugInteraction	gptkb:rifampin gptkb:carbamazepine antacids
gptkbp:effect	high barrier to resistance (newer agents)
gptkbp:eliminatedIn	urine feces
gptkbp:hasApprovedDrug	gptkb:raltegravir
https://www.w3.org/2000/01/rdf-schema#label	Integrase Strand Transfer Inhibitors
gptkbp:legalStatus	varies by drug
gptkbp:mechanismOfAction	inhibit HIV integrase enzyme
gptkbp:metabolism	liver
gptkbp:otherDrugs	gptkb:cabotegravir gptkb:dolutegravir gptkb:elvitegravir bictegravir
gptkbp:pregnancyCategory	consult specific drug
gptkbp:prevention	integration of viral DNA into host genome
gptkbp:resistantTo	possible with mutations in integrase gene
gptkbp:routeOfAdministration	oral injectable
gptkbp:sideEffect	nausea headache weight gain insomnia
gptkbp:target	gptkb:HIV-1_integrase gptkb:HIV-2_integrase
gptkbp:usedFor	HIV treatment
gptkbp:WHOStatus	included in WHO Model List of Essential Medicines
gptkbp:bfsParent	gptkb:INSTIs
gptkbp:bfsLayer	5