Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:glutamate--ammonia_ligase
GS |
| gptkbp:catalyzes |
synthesis of glutamine from glutamate and ammonia
|
| gptkbp:cofactor |
gptkb:ATP
Mg2+ |
| gptkbp:discoveredBy |
gptkb:David_M._Stadtman
|
| gptkbp:EC_number |
6.3.1.2
|
| gptkbp:foundIn |
gptkb:Bacteria
animals plants |
| gptkbp:function |
nitrogen metabolism
ammonia assimilation |
| gptkbp:gene |
gptkb:GLUL
|
| gptkbp:gene_symbol_(E._coli) |
gptkb:glnA
|
| gptkbp:GO_term |
ATP binding
glutamine biosynthetic process metal ion binding |
| https://www.w3.org/2000/01/rdf-schema#label |
Glutamine synthetase
|
| gptkbp:inhibitedBy |
gptkb:AMP
gptkb:CTP gptkb:glutamine tryptophan adenosine monophosphate serine glycine alanine histidine carbamoyl phosphate glucosamine-6-phosphate uridylylation |
| gptkbp:locatedIn |
gptkb:cytoplasm
|
| gptkbp:molecularWeight |
~42 kDa (per subunit)
|
| gptkbp:PDB |
gptkb:2GLS
|
| gptkbp:product |
gptkb:ADP
phosphate L-glutamine |
| gptkbp:regulates |
feedback inhibition
adenylylation covalent modification deadenylylation |
| gptkbp:significance |
involved in congenital glutamine synthetase deficiency
marker for astrocytes marker for hepatic encephalopathy |
| gptkbp:structure |
multimeric (typically dodecameric)
|
| gptkbp:substrate |
gptkb:ATP
gptkb:L-glutamate ammonia |
| gptkbp:UniProt_ID_(E._coli) |
P0A9H9
|
| gptkbp:UniProtID |
P15104
|
| gptkbp:bfsParent |
gptkb:Enzymes
|
| gptkbp:bfsLayer |
6
|