Gastrointestinal stromal tumor

URI: https://gptkb.org/entity/Gastrointestinal_stromal_tumor
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:disease
gptkbp:abbreviation gptkb:GIST
gptkbp:affects adults
children
gastrointestinal tract
gptkbp:annualIncidence 10-20 per million
gptkbp:diagnosedBy immunohistochemistry
gptkbp:firstDescribed 1983
gptkbp:frequency rare
gptkbp:hasMetastasisSite liver
peritoneum
rarely lymph nodes
https://www.w3.org/2000/01/rdf-schema#label Gastrointestinal stromal tumor
gptkbp:ICD-10_code C49.A
gptkbp:location stomach
gptkbp:malignantPotential variable
gptkbp:marking gptkb:CD117
gptkb:DOG1
gptkbp:MeSH_ID D018223
gptkbp:mutationAssociatedWith gptkb:KIT_gene
gptkb:PDGFRA_gene
gptkbp:notResponsiveTo radiation therapy
conventional chemotherapy
gptkbp:occurredIn colon
esophagus
rectum
gptkbp:OMIM 606764
gptkbp:origin gptkb:interstitial_cells_of_Cajal
gptkbp:prognosis depends on size and mitotic rate
gptkbp:relatedTo gptkb:rhabdomyosarcoma
gptkbp:riskFactor gptkb:neurofibromatosis_type_1
Carney's triad
gptkbp:secondMostCommonLocation gptkb:small_intestine
gptkbp:subspecies SDH-deficient GIST
pediatric GIST
wild-type GIST
gptkbp:symptom nausea
vomiting
abdominal pain
gastrointestinal bleeding
weight loss
gptkbp:treatment gptkb:imatinib
gptkb:regorafenib
gptkb:sunitinib
surgery
gptkbp:UMLS_CUI C0206686
gptkbp:bfsParent gptkb:GIST
gptkbp:bfsLayer 7