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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alternativeName
|
GLOD1
GLYI
lactoylglutathione lyase
|
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gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
gptkb:diabetes_mellitus
gptkb:autism_spectrum_disorder
schizophrenia
anxiety disorders
diabetic complications
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gptkbp:biologicalProcess
|
detoxification of methylglyoxal
lactoylglutathione lyase activity
|
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gptkbp:cellularComponent
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gptkb:cytoplasm
|
|
gptkbp:cofactor
|
zinc
|
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gptkbp:discoveredBy
|
early 20th century
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gptkbp:encodes
|
glyoxalase I protein
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gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000134574
2739
|
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gptkbp:expressedIn
|
gptkb:kidney
brain
heart
liver
|
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gptkbp:fullName
|
glyoxalase I
|
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gptkbp:function
|
catalyzes the detoxification of methylglyoxal
|
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gptkbp:geneType
|
protein-coding
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gptkbp:hasTranscriptVariant
|
multiple
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gptkbp:HGNC_ID
|
HGNC:4311
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|
https://www.w3.org/2000/01/rdf-schema#label
|
GLO1 gene
|
|
gptkbp:length
|
184 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
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gptkbp:location
|
gptkb:6p21.2
|
|
gptkbp:mutationAssociatedWith
|
may affect glyoxalase activity
may increase susceptibility to anxiety
|
|
gptkbp:OMIM
|
138750
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
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gptkbp:pathway
|
glutathione metabolism
glyoxalase system
methylglyoxal detoxification
|
|
gptkbp:product
|
glyoxalase I
|
|
gptkbp:protein_structure
|
homodimer
|
|
gptkbp:regulates
|
downregulated in diabetes
upregulated in some cancers
|
|
gptkbp:UniProtID
|
Q04760
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gptkbp:bfsParent
|
gptkb:chromosome_6_(human)
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gptkbp:bfsLayer
|
7
|