Statements (18)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:glucocerebrosidase
|
| gptkbp:associatedWith |
gptkb:Parkinson's_disease
gptkb:Gaucher_disease |
| gptkbp:deficiencyCauses |
accumulation of glucocerebroside in macrophages
|
| gptkbp:discoveredIn |
1965
|
| gptkbp:EC_number |
3.2.1.45
|
| gptkbp:encodedBy |
gptkb:GBA_gene
|
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
catalyzes the hydrolysis of glucocerebroside to glucose and ceramide
|
| https://www.w3.org/2000/01/rdf-schema#label |
GCase
|
| gptkbp:location |
gptkb:lysosome
|
| gptkbp:molecularWeight |
approximately 59 kDa
|
| gptkbp:structure |
gptkb:protein
|
| gptkbp:usedIn |
enzyme replacement therapy for Gaucher disease
|
| gptkbp:bfsParent |
gptkb:glucocerebrosidase
|
| gptkbp:bfsLayer |
7
|