Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:component |
central nervous system
|
| gptkbp:discoveredBy |
gptkb:Nico_van_Gelder
|
| gptkbp:effect |
hyperpolarization of neuron
inhibition of action potential |
| gptkbp:foundIn |
humans
mammals vertebrates |
| gptkbp:function |
mediates inhibitory neurotransmission
|
| gptkbp:gene |
gptkb:GABRD
gptkb:GABRG2 gptkb:GABRR1 gptkb:GABRR2 gptkb:GABRR3 GABRA1 GABRB2 GABRE GABRP GABRQ |
| https://www.w3.org/2000/01/rdf-schema#label |
GABA-A receptor complex
|
| gptkbp:ion_channel_type |
chloride channel
|
| gptkbp:ligand |
gptkb:benzodiazepines
gptkb:gamma-aminobutyric_acid_(GABA) gptkb:z-drugs ethanol barbiturates neurosteroids |
| gptkbp:location |
postsynaptic membrane
|
| gptkbp:MeSH_ID |
D005734
|
| gptkbp:modulatedBy |
anticonvulsants
anesthetics sedatives hypnotics |
| gptkbp:OMIM |
137160
|
| gptkbp:relatedTo |
gptkb:GABA-B_receptor
GABA-C receptor |
| gptkbp:structure |
pentameric
|
| gptkbp:subunit |
alpha subunit
beta subunit gamma subunit delta subunit epsilon subunit pi subunit rho subunit theta subunit |
| gptkbp:targetOfDrug |
anticonvulsants
anxiolytics muscle relaxants sedative-hypnotics |
| gptkbp:bfsParent |
gptkb:GABRA1_gene
|
| gptkbp:bfsLayer |
7
|