|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
GTP binding
|
|
gptkbp:amendedBy
|
gptkb:adenylate_cyclase
gptkb:phospholipase_C
ion channels
phosphodiesterases
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:McCune-Albright_syndrome
gptkb:whooping_cough
cholera
pseudohypoparathyroidism
|
|
gptkbp:awarded
|
Nobel Prize in Physiology or Medicine 1994
|
|
gptkbp:decommissioned
|
GTP hydrolysis
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman
|
|
gptkbp:domain
|
GTPase domain
helical domain
|
|
gptkbp:encodedBy
|
gptkb:GNA_genes
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
hydrolyzes GTP
binds guanine nucleotides
|
|
gptkbp:GO_term
|
GO:0004930
GO:0003924
GO:0007186
|
|
gptkbp:hasType
|
gptkb:Gα12/13
gptkb:Gαq
Gαi
Gαs
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
G-protein alpha subunits
|
|
gptkbp:interactsWith
|
gptkb:G-protein_beta_subunits
G-protein coupled receptors
effector proteins
G-protein gamma subunits
|
|
gptkbp:involvedIn
|
signal transduction
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~40 kDa
|
|
gptkbp:partOf
|
heterotrimeric G protein
|
|
gptkbp:PDB
|
gptkb:1AZT
1AGR
1GIA
|
|
gptkbp:postTranslationalModification
|
palmitoylation
myristoylation
ADP-ribosylation
|
|
gptkbp:regulates
|
gptkb:IP3/DAG_pathway
cAMP levels
calcium signaling
second messenger systems
|
|
gptkbp:bfsParent
|
gptkb:CAV1
gptkb:PLCB1
|
|
gptkbp:bfsLayer
|
7
|