|
gptkbp:instanceOf
|
antibiotic class
|
|
gptkbp:administeredBy
|
oral
topical
intravenous
|
|
gptkbp:alternativeName
|
fluorinated quinolones
|
|
gptkbp:book
|
ciprofloxacin
|
|
gptkbp:category
|
synthetic antibiotics
|
|
gptkbp:contraindication
|
children
pregnancy
|
|
gptkbp:developedBy
|
gptkb:Kyorin_Pharmaceutical
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:drugInteraction
|
gptkb:theophylline
gptkb:warfarin
antacids
|
|
gptkbp:effect
|
Gram-negative bacteria
some Gram-positive bacteria
|
|
gptkbp:example
|
gptkb:moxifloxacin
gptkb:levofloxacin
gptkb:norfloxacin
gptkb:ofloxacin
ciprofloxacin
|
|
gptkbp:excretion
|
kidneys
|
|
gptkbp:FDAWarning
|
serious side effects
|
|
gptkbp:firstBook
|
gptkb:norfloxacin
|
|
gptkbp:fourthGenerationYears
|
gptkb:moxifloxacin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fluoroquinolones
|
|
gptkbp:mechanismOfAction
|
inhibit DNA gyrase
inhibit topoisomerase IV
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notEffectiveAgainst
|
anaerobes
|
|
gptkbp:notRecommendedFor
|
mild infections
|
|
gptkbp:regulates
|
prescription only
|
|
gptkbp:resistantTo
|
efflux pumps
mutations in DNA gyrase
|
|
gptkbp:riskFactor
|
gptkb:Clostridioides_difficile_infection
peripheral neuropathy
CNS effects
tendinitis
|
|
gptkbp:sideEffect
|
QT prolongation
photosensitivity
gastrointestinal upset
tendon rupture
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:structureContains
|
fluorine atom
quinolone core
|
|
gptkbp:thirdPlace
|
gptkb:levofloxacin
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:WHOStatus
|
gptkb:Essential_Medicines
|
|
gptkbp:bfsParent
|
gptkb:Antibiotics
|
|
gptkbp:bfsLayer
|
4
|