|
gptkbp:instanceOf
|
gptkb:antibiotic
fluoroquinolone
|
|
gptkbp:approvedBy
|
gptkb:FDA
1986
|
|
gptkbp:ATCCode
|
J01MA06
|
|
gptkbp:bioavailability
|
30-40%
|
|
gptkbp:brand
|
Chibroxin
Noroxin
|
|
gptkbp:CASNumber
|
70458-96-7
|
|
gptkbp:category
|
gptkb:drug
|
|
gptkbp:chemicalClass
|
quinolone
|
|
gptkbp:contraindication
|
children
pregnancy
|
|
gptkbp:discoveredBy
|
gptkb:Kyorin_Pharmaceutical
|
|
gptkbp:eliminationHalfLife
|
3-4 hours
|
|
gptkbp:excretion
|
renal
fecal
|
|
gptkbp:hasMolecularFormula
|
C16H18FN3O3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
norfloxacin
|
|
gptkbp:interactsWith
|
gptkb:theophylline
gptkb:warfarin
caffeine
antacids
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits DNA gyrase
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
10-15%
|
|
gptkbp:riskFactor
|
gptkb:Clostridioides_difficile_infection
peripheral neuropathy
QT prolongation
tendinitis
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
dizziness
headache
rash
|
|
gptkbp:synonym
|
(+/-)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
|
|
gptkbp:usedFor
|
gptkb:prostatitis
urinary tract infection
gastroenteritis
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
no
|
|
gptkbp:bfsParent
|
gptkb:Fluoroquinolones
|
|
gptkbp:bfsLayer
|
5
|