Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:CD32A
FcgammaRIIA |
| gptkbp:associatedWith |
gptkb:immune_thrombocytopenic_purpura
gptkb:systemic_lupus_erythematosus autoimmune diseases |
| gptkbp:biologicalProcess |
signal transduction
receptor activity immune system process immunoglobulin binding |
| gptkbp:cellularComponent |
gptkb:plasma_membrane
|
| gptkbp:discoveredBy |
multiple researchers
|
| gptkbp:encodes |
Fc gamma receptor IIa (CD32a)
|
| gptkbp:Entrez_Gene_ID |
2212
ENSG00000143226 GC01M161425 |
| gptkbp:expressedIn |
macrophages
myeloid cells monocytes neutrophils |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:fullName |
Fc fragment of IgG receptor IIa
|
| gptkbp:function |
involved in immune response
encodes a receptor for the Fc region of immunoglobulin G (IgG) involved in phagocytosis |
| gptkbp:hasPolymorphism |
rs1801274
|
| gptkbp:hasTranscriptVariant |
multiple
|
| gptkbp:HGNC_ID |
3617
|
| https://www.w3.org/2000/01/rdf-schema#label |
FCGR2A gene
|
| gptkbp:interactsWith |
gptkb:immunoglobulin_G
complement system |
| gptkbp:length |
297 amino acids
|
| gptkbp:locatedOnChromosome |
chromosome 1
1q23.3 |
| gptkbp:molecularWeight |
32 kDa
|
| gptkbp:mutationAssociatedWith |
alters susceptibility to infection
modifies response to monoclonal antibody therapy |
| gptkbp:OMIM |
146790
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Fcgr2
Fcgr2a |
| gptkbp:pathway |
gptkb:adaptive_immune_system
innate immune system Fc gamma R-mediated phagocytosis |
| gptkbp:product |
CD32A protein
|
| gptkbp:regulates |
inflammatory response
antibody-dependent cellular cytotoxicity |
| gptkbp:UniProtID |
P12318
|
| gptkbp:bfsParent |
gptkb:CD32
|
| gptkbp:bfsLayer |
7
|