E2 conjugating enzyme UBE2I

URI: https://gptkb.org/entity/E2_conjugating_enzyme_UBE2I
GPTKB entity
Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs SUMO-conjugating enzyme UBC9
Ubc9
gptkbp:associatedWith cancer (dysregulation)
gptkbp:biologicalProcess cell cycle regulation
regulation of transcription
protein sumoylation
gptkbp:discoveredBy 1996
gptkbp:encodedBy UBE2I gene
gptkbp:Entrez_Gene_ID 7329
gptkbp:enzymeCommissionNumber EC 2.3.2.23
gptkbp:function SUMO-conjugating enzyme
involved in sumoylation
gptkbp:gene UBE2I
gptkbp:HGNC_ID 12496
https://www.w3.org/2000/01/rdf-schema#label E2 conjugating enzyme UBE2I
gptkbp:interactsWith gptkb:SUMO1
gptkb:SUMO2
gptkb:SUMO3
gptkb:RanGAP1
gptkb:PIAS1
gptkbp:length 158 amino acids
gptkbp:locatedOnChromosome 16p13.3
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~18 kDa
gptkbp:OMIM 601661
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse Ube2i
gptkbp:orthologInYeast UBC9
gptkbp:PDB 1U9A
2GRN
3UIP
gptkbp:postTranslationalModification phosphorylation
sumoylation
gptkbp:RefSeq NM_003345
NP_003336
gptkbp:requires SUMO modification pathway
gptkbp:structure contains UBCc domain
gptkbp:UniProtID P63279
gptkbp:bfsParent gptkb:SUMO3
gptkbp:bfsLayer 8