Duffy antigen receptor for chemokines

URI: https://gptkb.org/entity/Duffy_antigen_receptor_for_chemokines
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alsoKnownAs gptkb:ACKR1
gptkb:DARC
CD234
gptkbp:alternativeSplicing yes
gptkbp:antigenicDeterminants Fya
Fyb
Fy10
Fy11
Fy12
Fy3
Fy4
Fy5
Fy6
Fy7
Fy8
Fy9
FyX
gptkbp:associatedWith inflammatory diseases
benign ethnic neutropenia
gptkbp:binds chemokines
gptkbp:bloodGroupSystem gptkb:Duffy_blood_group_system
gptkbp:discoveredBy Marion Duffy
gptkbp:encodedBy gptkb:ACKR1_gene
gptkbp:Entrez_Gene_ID 2532
gptkbp:expressedIn red blood cells
endothelial cells
gptkbp:firstDescribed 1950
gptkbp:function chemokine receptor
blood group antigen
gptkbp:geneType protein-coding
gptkbp:HGNC_ID HGNC:251
https://www.w3.org/2000/01/rdf-schema#label Duffy antigen receptor for chemokines
gptkbp:locatedOnChromosome chromosome 1
gptkbp:molecularWeight ~35 kDa
gptkbp:mutationAssociatedWith Fy(a-b-) phenotype
Duffy-null phenotype
gptkbp:OMIM 110700
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Pan_troglodytes
gptkbp:significance malaria resistance
Plasmodium vivax entry receptor
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure seven-transmembrane protein
gptkbp:transmembraneDomains 7
gptkbp:UniProtID Q16570
gptkbp:bfsParent gptkb:CD296
gptkb:ACKR1_gene
gptkbp:bfsLayer 8