|
gptkbp:instanceOf
|
gptkb:protein
gptkb:solute_carrier_family
amino acid transporter
|
|
gptkbp:alias
|
gptkb:DAT
gptkb:SLC6A3
dopamine reuptake transporter
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
gptkb:attention_deficit_hyperactivity_disorder
bipolar disorder
schizophrenia
substance abuse
|
|
gptkbp:expressedIn
|
gptkb:striatum
gptkb:ventral_tegmental_area
gptkb:olfactory_bulb
gptkb:nucleus_accumbens
substantia nigra
hypothalamus
|
|
gptkbp:foundIn
|
central nervous system
presynaptic neuron
|
|
gptkbp:function
|
reuptake of dopamine from synaptic cleft
regulation of dopamine neurotransmission
|
|
gptkbp:gene
|
gptkb:SLC6A3
|
|
gptkbp:HGNC_ID
|
11049
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dopamine transporter
|
|
gptkbp:inhibitedBy
|
gptkb:benztropine
gptkb:methylphenidate
cocaine
amphetamine
GBR-12909
|
|
gptkbp:locatedOnChromosome
|
gptkb:5p15.33
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:number_of_amino_acids
|
620
|
|
gptkbp:OMIM
|
126455
|
|
gptkbp:orthologInMouse
|
gptkb:Slc6a3
|
|
gptkbp:orthologInZebrafish
|
slc6a3
|
|
gptkbp:PDB
|
gptkb:4XPA
|
|
gptkbp:structure
|
12 transmembrane domains
|
|
gptkbp:target
|
gptkb:sertraline
gptkb:bupropion
gptkb:benztropine
gptkb:modafinil
gptkb:nomifensine
gptkb:methylphenidate
cocaine
amphetamine
mazindol
GBR-12909
|
|
gptkbp:UniProtID
|
gptkb:Q01959
|
|
gptkbp:bfsParent
|
gptkb:Dopamine_(in_brain)
gptkb:P30613
|
|
gptkbp:bfsLayer
|
8
|