modafinil

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:drug
eugeroic
gptkbp:approvalYear 1998 (US)
gptkbp:approvedBy gptkb:European_Union
gptkb:United_States
gptkbp:ATCCode gptkb:N06BA07
gptkbp:bioavailability 80-90%
gptkbp:brand gptkb:Provigil
gptkbp:CASNumber gptkb:68693-11-8
gptkbp:category gptkb:drug
stimulant
nootropic
wakefulness-promoting agent
gptkbp:chemicalClass benzhydryl sulfinyl compound
gptkbp:contraindication hypersensitivity to modafinil
gptkbp:controlledSubstanceSchedule Schedule IV (US)
gptkbp:developedBy gptkb:Lafon_Laboratories
gptkbp:discoveredBy gptkb:Michel_Jouvet
gptkbp:eliminationHalfLife 12-15 hours
gptkbp:excretion urine
gptkbp:firstSynthesized 1970s
gptkbp:hasMolecularFormula gptkb:C15H15NO2S
https://www.w3.org/2000/01/rdf-schema#label modafinil
gptkbp:IUPACName gptkb:2-[(diphenylmethyl)sulfinyl]acetamide
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction dopamine reuptake inhibitor
histamine release
orexin activation
gptkbp:metabolism liver
gptkbp:offLabelUse gptkb:depression
ADHD
cognitive enhancement
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 60%
gptkbp:PubChem_CID gptkb:DB00745
CHEMBL651
4236
gptkbp:riskOfDependence low
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
anxiety
headache
nervousness
insomnia
gptkbp:synonym gptkb:2-[(diphenylmethyl)sulfinyl]acetamide
gptkbp:UNII R3T0OMM39T
gptkbp:usedFor gptkb:shift_work_sleep_disorder
narcolepsy
obstructive sleep apnea
gptkbp:bfsParent gptkb:BALCO_scandal
gptkb:dopamine_transporter
gptkb:Shift_work_sleep_disorder
gptkb:@gwern
gptkbp:bfsLayer 7