|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
DEPDC6
|
|
gptkbp:associatedWith
|
gptkb:cancer
multiple myeloma
|
|
gptkbp:discoveredIn
|
2009
|
|
gptkbp:encodes
|
gptkb:DEP_domain-containing_mTOR-interacting_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000162630
64798
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:function
|
negative regulator of mTOR signaling
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:29022
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DEPTOR gene
|
|
gptkbp:inhibitedBy
|
mTOR kinase activity
|
|
gptkbp:involvedIn
|
cell survival
metabolism
cell growth
protein synthesis
autophagy
insulin signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24.12
chromosome 8
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:orthologInMouse
|
gptkb:Deptor
|
|
gptkbp:phosphorylates
|
Serine 235
Serine 286
Serine 293
Serine 299
Serine 367
Serine 371
Serine 383
Serine 394
Serine 398
Serine 402
Serine 407
Serine 411
Serine 422
Serine 426
Serine 430
Serine 434
Serine 438
Serine 442
Serine 446
|
|
gptkbp:product
|
DEPTOR protein
|
|
gptkbp:proteinFamily
|
DEP domain
PDZ domain
|
|
gptkbp:regulates
|
gptkb:mTORC1
gptkb:mTORC2
regulated by mTOR activity
transcriptionally regulated by FOXO3
|
|
gptkbp:UniProtID
|
gptkb:Q8TB45
|
|
gptkbp:bfsParent
|
gptkb:Deptor
|
|
gptkbp:bfsLayer
|
6
|