DB09330

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2013
gptkbp:ATCCode gptkb:J05AP08
gptkbp:bioavailability ~80%
gptkbp:brand gptkb:Sovaldi
gptkbp:CASNumber 1190307-88-0
gptkbp:category prodrug
nucleotide
direct-acting antiviral
gptkbp:contraindication co-administration with amiodarone
gptkbp:developer gptkb:Gilead_Sciences
gptkbp:drugInteraction gptkb:phenytoin
gptkb:rifampin
gptkb:carbamazepine
gptkb:St._John's_Wort
gptkbp:eliminationHalfLife 0.4 hours (sofosbuvir), 27 hours (GS-331007)
gptkbp:excretion urine
gptkbp:hasInChIKey YYOQXSRSLFDYER-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C22H29FN3O9P
gptkbp:hasSMILES CC(C)COC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@@](C#N)(c2ccc(F)cc2)[C@H](O)[C@@H]1O)Oc1ccccc1
gptkbp:hasUNII Q1Q1J2J1NG
https://www.w3.org/2000/01/rdf-schema#label DB09330
gptkbp:indication treatment of chronic hepatitis C infection
gptkbp:isAntiviral true
gptkbp:isProdrug true
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits HCV NS5B polymerase
gptkbp:metabolism liver
gptkbp:molecularWeight 529.45
gptkbp:name gptkb:Sofosbuvir
gptkbp:pregnancyCategory B1 (Australia)
gptkbp:proteinBinding 61-65%
gptkbp:PubChem_CID gptkb:DB09330
gptkb:D10366
45375808
CHEMBL1257078
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
fatigue
headache
insomnia
gptkbp:status true
gptkbp:synonym gptkb:Sovaldi
gptkb:GS-7977
gptkb:PSI-7977
gptkbp:target NS5B RNA-dependent RNA polymerase
gptkbp:bfsParent gptkb:162359-55-9
gptkbp:bfsLayer 6