gptkbp:instanceOf
|
gptkb:drug
|
gptkbp:approvalYear
|
2013
|
gptkbp:ATCCode
|
gptkb:J05AP08
|
gptkbp:bioavailability
|
~80%
|
gptkbp:brand
|
gptkb:Sovaldi
|
gptkbp:CASNumber
|
1190307-88-0
|
gptkbp:category
|
prodrug
nucleotide
direct-acting antiviral
|
gptkbp:contraindication
|
co-administration with amiodarone
|
gptkbp:developer
|
gptkb:Gilead_Sciences
|
gptkbp:drugInteraction
|
gptkb:phenytoin
gptkb:rifampin
gptkb:carbamazepine
gptkb:St._John's_Wort
|
gptkbp:eliminationHalfLife
|
0.4 hours (sofosbuvir), 27 hours (GS-331007)
|
gptkbp:excretion
|
urine
|
gptkbp:hasInChIKey
|
YYOQXSRSLFDYER-UHFFFAOYSA-N
|
gptkbp:hasMolecularFormula
|
C22H29FN3O9P
|
gptkbp:hasSMILES
|
CC(C)COC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@@](C#N)(c2ccc(F)cc2)[C@H](O)[C@@H]1O)Oc1ccccc1
|
gptkbp:hasUNII
|
Q1Q1J2J1NG
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB09330
|
gptkbp:indication
|
treatment of chronic hepatitis C infection
|
gptkbp:isAntiviral
|
true
|
gptkbp:isProdrug
|
true
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
inhibits HCV NS5B polymerase
|
gptkbp:metabolism
|
liver
|
gptkbp:molecularWeight
|
529.45
|
gptkbp:name
|
gptkb:Sofosbuvir
|
gptkbp:pregnancyCategory
|
B1 (Australia)
|
gptkbp:proteinBinding
|
61-65%
|
gptkbp:PubChem_CID
|
gptkb:DB09330
gptkb:D10366
45375808
CHEMBL1257078
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
gptkb:anemia
nausea
fatigue
headache
insomnia
|
gptkbp:status
|
true
|
gptkbp:synonym
|
gptkb:Sovaldi
gptkb:GS-7977
gptkb:PSI-7977
|
gptkbp:target
|
NS5B RNA-dependent RNA polymerase
|
gptkbp:bfsParent
|
gptkb:162359-55-9
|
gptkbp:bfsLayer
|
6
|