PSI-7977

URI: https://gptkb.org/entity/PSI-7977

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:antiviral_drug
gptkbp:alsoKnownAs	gptkb:Sofosbuvir
gptkbp:approvalYear	2013
gptkbp:approvedBy	gptkb:FDA
gptkbp:ATCCode	gptkb:J05AX15
gptkbp:CASNumber	1190307-88-0
gptkbp:chemicalFormula	C22H29FN3O9P
gptkbp:combinationTherapy	gptkb:peginterferon_alfa ribavirin ledipasvir velpatasvir
gptkbp:developedBy	gptkb:Gilead_Sciences gptkb:Pharmasset
gptkbp:drugClass	gptkb:nucleotide
gptkbp:eliminationHalfLife	0.4 hours (sofosbuvir), 27 hours (GS-331007 metabolite)
gptkbp:legalStatus	prescription only
gptkbp:marketedAs	gptkb:Sovaldi
gptkbp:mechanismOfAction	inhibits HCV NS5B polymerase
gptkbp:metabolism	gptkb:GS-331007
gptkbp:patent	gptkb:Gilead_Sciences
gptkbp:pregnancyCategory	B1 (Australia)
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	gptkb:anemia nausea fatigue headache insomnia
gptkbp:usedFor	treatment of hepatitis C
gptkbp:WHOModelListOfEssentialMedicines	yes
gptkbp:bfsParent	gptkb:sofosbuvir
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	PSI-7977