PSI-7977

URI: https://gptkb.org/entity/PSI-7977
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:antiviral_drug
gptkbp:alsoKnownAs gptkb:Sofosbuvir
gptkbp:approvalYear 2013
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode gptkb:J05AX15
gptkbp:CASNumber 1190307-88-0
gptkbp:chemicalFormula C22H29FN3O9P
gptkbp:combinationTherapy gptkb:peginterferon_alfa
ribavirin
ledipasvir
velpatasvir
gptkbp:developedBy gptkb:Gilead_Sciences
gptkb:Pharmasset
gptkbp:drugClass gptkb:nucleotide
gptkbp:eliminationHalfLife 0.4 hours (sofosbuvir), 27 hours (GS-331007 metabolite)
gptkbp:legalStatus prescription only
gptkbp:marketedAs gptkb:Sovaldi
gptkbp:mechanismOfAction inhibits HCV NS5B polymerase
gptkbp:metabolism gptkb:GS-331007
gptkbp:patent gptkb:Gilead_Sciences
gptkbp:pregnancyCategory B1 (Australia)
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
fatigue
headache
insomnia
gptkbp:usedFor treatment of hepatitis C
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:sofosbuvir
gptkbp:bfsLayer 6
https://www.w3.org/2000/01/rdf-schema#label PSI-7977