Pradaxa

GPTKB entity

Statements (34)
Predicate Object
gptkbp:instanceOf anticoagulant medication
gptkbp:antidote gptkb:idarucizumab
gptkbp:approvalYear 2010
gptkbp:ATCCode B01AE07
gptkbp:bioavailability 3-7%
gptkbp:brand gptkb:Pradaxa
gptkbp:contraindication active pathological bleeding
mechanical prosthetic heart valve
gptkbp:drugClass gptkb:anticoagulant
gptkbp:excretion renal
gptkbp:form capsule
gptkbp:genericName dabigatran etexilate
gptkbp:halfLife 12-17 hours
gptkbp:hasBoxedWarning risk of spinal/epidural hematoma
https://www.w3.org/2000/01/rdf-schema#label Pradaxa
gptkbp:indication prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
gptkbp:legalStatus prescription only
gptkbp:manufacturer gptkb:Boehringer_Ingelheim
gptkbp:mechanismOfAction direct thrombin inhibitor
gptkbp:metabolism hepatic
gptkbp:pregnancyCategory C (US)
B3 (Australia)
gptkbp:proteinBinding 35%
gptkbp:riskFactor increased risk of bleeding with concomitant use of other anticoagulants
gptkbp:routeOfAdministration oral
gptkbp:sideEffect bleeding
gastrointestinal upset
gptkbp:bfsParent gptkb:Boehringer_Ingelheim
gptkb:DB09054
gptkb:DB12023
gptkb:dabigatran
gptkbp:bfsLayer 6