Dabigatran etexilate

GPTKB entity

Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:anticoagulant
direct thrombin inhibitor
gptkbp:antidote gptkb:idarucizumab
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2008
gptkbp:ATCCode B01AE07
gptkbp:bioavailability 3-7%
gptkbp:brand gptkb:Pradaxa
gptkbp:CASNumber 211915-06-9
gptkbp:contraindication severe renal impairment
active pathological bleeding
gptkbp:developedBy gptkb:Boehringer_Ingelheim
gptkbp:drugClass NOAC (novel oral anticoagulant)
gptkbp:eliminationHalfLife 12-17 hours
gptkbp:excretion renal
gptkbp:hasMolecularFormula C34H41N7O5
https://www.w3.org/2000/01/rdf-schema#label Dabigatran etexilate
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits thrombin (factor IIa)
gptkbp:metabolism liver
gptkbp:molecularWeight 627.74 g/mol
gptkbp:patentExpired 2023 (US)
gptkbp:pregnancyCategory C (US)
gptkbp:prodrugOf gptkb:dabigatran
gptkbp:proteinBinding 35%
gptkbp:riskFactor increased bleeding with P-gp inhibitors
not recommended in mechanical heart valves
gptkbp:routeOfAdministration oral
gptkbp:sideEffect bleeding
gastrointestinal upset
gptkbp:storage store at room temperature, protect from moisture
gptkbp:usedFor prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
gptkbp:bfsParent gptkb:DB09054
gptkbp:bfsLayer 6