DB09052

GPTKB entity

Statements (59)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2013
gptkbp:ATCCode gptkb:J05AP08
gptkbp:bioavailability high
gptkbp:brand gptkb:Vemlidy
gptkb:Sovaldi
gptkbp:CASNumber 1190307-88-0
gptkbp:category gptkb:NS5B_polymerase_inhibitor
nucleotide
direct-acting antiviral
gptkbp:contraindication hypersensitivity to sofosbuvir
gptkbp:drugClass antiviral drug
gptkbp:drugInteraction gptkb:phenytoin
gptkb:rifampin
gptkb:ritonavir
gptkb:carbamazepine
gptkb:tipranavir
gptkb:St._John's_Wort
gptkb:oxcarbazepine
phenobarbital
amiodarone
gptkbp:eliminatedIn renal
gptkbp:eliminationHalfLife 0.4 hours (sofosbuvir), 27 hours (GS-331007)
gptkbp:hasActiveMetabolite gptkb:GS-331007
gptkbp:hasInChIKey YYOQXSRSLFDJOM-QZIXMDIESA-N
gptkbp:hasMolecularFormula C22H29FN3O9P
gptkbp:hasPatentExpiry 2029 (US)
gptkbp:hasPatentHolder gptkb:Gilead_Sciences
gptkbp:hasSMILES CC(C)COC(=O)[C@H](NC(=O)[C@@H]1O[C@@](C#N)(CO)[C@H](O)[C@@H]1O)P(=O)(OCC2=CC=CC=C2)OCC3=CC=CC=C3
gptkbp:hasUNII SOF2X721MH
https://www.w3.org/2000/01/rdf-schema#label DB09052
gptkbp:indication treatment of chronic hepatitis C infection
gptkbp:isProdrug true
gptkbp:IUPACName Isopropyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction NS5B RNA-dependent RNA polymerase inhibitor
gptkbp:metabolism liver
gptkbp:molecularWeight 529.45
gptkbp:name gptkb:Sofosbuvir
gptkbp:pregnancyCategory B1 (Australia)
gptkbp:proteinBinding 61-65%
gptkbp:PubChem_CID gptkb:DB09052
gptkb:D10366
45375808
CHEMBL1257078
28530408
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
fatigue
headache
insomnia
gptkbp:status true
gptkbp:synonym gptkb:Sovaldi
gptkb:GS-7977
gptkb:PSI-7977
gptkbp:target NS5B protein
gptkbp:bfsParent gptkb:Tianeptine
gptkbp:bfsLayer 7