DB00713

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994 (US)
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:color white
gptkbp:contraindication metabolic acidosis
renal impairment
acute or chronic metabolic acidosis
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion gptkb:kidney
gptkbp:form gptkb:tablet
oral solution
gptkbp:hasChEMBL gptkb:CHEMBL1431
gptkbp:hasDrugBankURL https://go.drugbank.com/drugs/DB00713
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB00713
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkb:polycystic_ovary_syndrome_(off-label)
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
decreases intestinal absorption of glucose
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:originatedIn synthetic
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID 6801
4091
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
abdominal pain
gastrointestinal upset
lactic acidosis
gptkbp:synonym 1,1-dimethylbiguanide
dimethylbiguanide
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkbp:usedFor gptkb:type_2_diabetes_mellitus
gptkbp:bfsParent gptkb:oxacillin
gptkbp:bfsLayer 7