|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
|
gptkbp:ATCCode
|
A10BA02
|
|
gptkbp:bioavailability
|
50–60%
|
|
gptkbp:CASNumber
|
657-24-9
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
metabolic acidosis
renal impairment
|
|
gptkbp:discoveredBy
|
gptkb:James_Bell
gptkb:Emile_Werner
|
|
gptkbp:discoveredIn
|
1922
|
|
gptkbp:drugClass
|
biguanide
|
|
gptkbp:eliminationHalfLife
|
4–8.7 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:firstMarketedYear
|
1957
|
|
gptkbp:flavor
|
bitter
|
|
gptkbp:hasInChIKey
|
gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C4H11N5
|
|
gptkbp:hasSMILES
|
CN(C)C(=N)N=C(N)N
|
|
gptkbp:hasUNII
|
9100L32L2N
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB00705
|
|
gptkbp:indication
|
gptkb:polycystic_ovary_syndrome
gptkb:gestational_diabetes
gptkb:prediabetes
|
|
gptkbp:isApprovedDrug
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:KEGGID
|
D04941
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
decreases hepatic glucose production
increases insulin sensitivity
|
|
gptkbp:meltingPoint
|
223–226 °C
|
|
gptkbp:metabolism
|
not metabolized
|
|
gptkbp:molecularWeight
|
129.164 g/mol
|
|
gptkbp:name
|
gptkb:Metformin
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:proteinBinding
|
negligible
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1431
gptkb:DB00705
4091
3944
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gastrointestinal upset
lactic acidosis
|
|
gptkbp:solubility
|
freely soluble in water
|
|
gptkbp:synonym
|
gptkb:Glucophage
gptkb:Metformina
gptkb:Metformine
gptkb:Dimethylbiguanide
|
|
gptkbp:target
|
gptkb:AMP-activated_protein_kinase
gptkb:mitochondrial_respiratory_chain_complex_I
|
|
gptkbp:usedFor
|
gptkb:type_2_diabetes_mellitus
|
|
gptkbp:bfsParent
|
gptkb:delavirdine
|
|
gptkbp:bfsLayer
|
6
|