DB00624

GPTKB entity

Statements (56)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:CASNumber 657-24-9
gptkbp:color white
gptkbp:contraindication renal impairment
hepatic impairment
acute or chronic metabolic acidosis
gptkbp:drugClass biguanide
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:form gptkb:tablet
oral solution
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB00624
gptkbp:indication gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
gptkbp:KEGGID D04941
gptkbp:legalStatus expired
prescription only
gptkbp:manufacturer gptkb:Bristol-Myers_Squibb
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
gptkbp:meltingPoint 223-226°C
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:DB00624
6801
4091
3949
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
abdominal pain
gastrointestinal upset
lactic acidosis
gptkbp:status true
gptkbp:synonym gptkb:Glucophage
gptkb:Metformina
gptkb:Metformine
gptkb:Metforminum
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkb:mitochondrial_respiratory_chain_complex_I
gptkbp:usedFor gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
gptkbp:bfsParent gptkb:Testosterone
gptkb:Dihydrotestosterone_(DHT)
gptkb:DHT
gptkbp:bfsLayer 7