DB00603

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:color white
gptkbp:contraindication metabolic acidosis
renal impairment
gptkbp:discoveredBy gptkb:Jean_Sterne
gptkbp:discoveredIn 1957
gptkbp:drugClass biguanide
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion gptkb:kidney
gptkbp:form gptkb:government_agency
gptkb:tablet
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C4H11N5
gptkbp:hasRoute oral
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
gptkbp:hasUNII 9100L32L2N
gptkbp:hasWikipediaPage gptkb:Metformin
https://www.w3.org/2000/01/rdf-schema#label DB00603
gptkbp:isApprovedDrug true
gptkbp:isGeneric true
gptkbp:KEGGID D04968
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
gptkbp:MeSH_ID D008687
gptkbp:metabolism not significantly metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:CHEMBL1431
gptkb:DB00603
4091
3947
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gastrointestinal upset
lactic acidosis
gptkbp:usedFor gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
gptkbp:WHOEssentialMedicineList yes
gptkbp:bfsParent gptkb:medroxyprogesterone_acetate
gptkbp:bfsLayer 7