DB00434

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:category antidiabetic agent
biguanide
gptkbp:contraindication metabolic acidosis
renal impairment
gptkbp:eliminatedIn urine
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:form C4H11N5
https://www.w3.org/2000/01/rdf-schema#label DB00434
gptkbp:inchiKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkbp:KEGGID gptkb:D01841
gptkbp:legalStatus prescription only
gptkbp:maximumPlasmaConcentrationTime 2.5 hours
gptkbp:mechanismOfAction improves insulin sensitivity
decreases hepatic glucose production
decreases intestinal absorption of glucose
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:origin synthetic
gptkbp:pharmacodynamics reduces blood glucose without causing hypoglycemia
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:CHEMBL1431
gptkb:DB00434
4091
3949
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
gastrointestinal upset
lactic acidosis
gptkbp:smiles CN(C)C(=N)N=C(N)N
gptkbp:status approved
gptkbp:synonym 1,1-dimethylbiguanide
dimethylbiguanide
gptkbp:target gptkb:AMP-activated_protein_kinase
gptkbp:toxicity overdose may cause lactic acidosis
gptkbp:UNII 9100L32L2N
gptkbp:bfsParent gptkb:cyproheptadine
gptkbp:bfsLayer 7