Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
gptkb:Cysteine
Histidine |
| gptkbp:alternativeName |
thiol protease
|
| gptkbp:biologicalProcess |
apoptosis
cell signaling protein degradation antigen processing |
| gptkbp:catalyzes |
hydrolysis of peptide bonds
|
| gptkbp:cofactor |
none required
|
| gptkbp:enzymeClassification |
EC 3.4.22
|
| gptkbp:example |
gptkb:Caspase
gptkb:Papain Bromelain Calpain Cathepsin B |
| gptkbp:family |
Calpain family
Caspase family Legumain family Papain-like proteases Ubiquitin-specific proteases |
| gptkbp:firstDescribed |
early 20th century
|
| gptkbp:foundIn |
gptkb:Plants
gptkb:Bacteria Animals Viruses |
| gptkbp:GO_term |
GO:0004197
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cysteine protease
|
| gptkbp:importantFor |
essential for many physiological processes
|
| gptkbp:inhibitedBy |
gptkb:Cystatin
E-64 Leupeptin |
| gptkbp:inhibitorType |
endogenous inhibitors
synthetic inhibitors |
| gptkbp:mechanismOfAction |
nucleophilic attack by cysteine thiol
|
| gptkbp:optimum_pH |
varies by enzyme, often acidic or neutral
|
| gptkbp:PDBStructureAvailable |
Yes
|
| gptkbp:significance |
involved in neurodegenerative diseases
involved in parasitic infections involved in diseases such as cancer |
| gptkbp:structure |
contains catalytic dyad or triad
|
| gptkbp:substrate |
proteins
peptides |
| gptkbp:usedIn |
gptkb:biotechnology
therapeutics meat tenderization |
| gptkbp:bfsParent |
gptkb:Peptidase
|
| gptkbp:bfsLayer |
7
|