|
gptkbp:instance_of
|
gptkb:chemical_compound
|
|
gptkbp:bfsLayer
|
6
|
|
gptkbp:bfsParent
|
gptkb:R-CHOP
|
|
gptkbp:affects
|
rapidly dividing cells
|
|
gptkbp:appointed_by
|
oral tablet
intravenous injection
|
|
gptkbp:approves
|
gptkb:1959
gptkb:FDA
|
|
gptkbp:associated_with
|
fertility issues
cardiotoxicity
pulmonary toxicity
secondary malignancies
hemorrhagic cystitis
|
|
gptkbp:brand
|
gptkb:Cytoxan
|
|
gptkbp:can_be_used_with
|
gptkb:methotrexate
gptkb:cisplatin
gptkb:doxorubicin
|
|
gptkbp:class
|
gptkb:weapon
|
|
gptkbp:contraindication
|
pregnancy
active infections
severe bone marrow suppression
|
|
gptkbp:discovered_by
|
George H. Hitchings
|
|
gptkbp:established
|
protein synthesis
DNA synthesis
RNA synthesis
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cyclophosphamide
|
|
gptkbp:ingredients
|
C7 H15 Cl2 N2 O2 P
|
|
gptkbp:interacts_with
|
gptkb:warfarin
gptkb:dexamethasone
mesna
|
|
gptkbp:is_analyzed_in
|
clinical trials
immunosuppressive therapy
stem cell transplantation
|
|
gptkbp:is_available_on
|
generic drug
|
|
gptkbp:is_used_for
|
gptkb:healthcare_organization
autoimmune diseases
|
|
gptkbp:lifespan
|
7 to 14 hours
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:produced_by
|
gptkb:chemical_compound
|
|
gptkbp:related_to
|
gptkb:ifosfamide
gptkb:chlorambucil
nitrogen mustard
|
|
gptkbp:side_effect
|
nausea
vomiting
hair loss
bone marrow suppression
increased risk of infection
|
|
gptkbp:targets
|
gptkb:DJ
|
|
gptkbp:type_of
|
6055-19-2
|
|
gptkbp:used_in
|
leukemia treatment
breast cancer treatment
multiple myeloma treatment
lymphoma treatment
ovarian cancer treatment
|