Cu,Zn-superoxide dismutase

URI: https://gptkb.org/entity/Cu,Zn-superoxide_dismutase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:SOD1
gptkbp:associatedWith amyotrophic lateral sclerosis
gptkbp:cofactor copper
zinc
gptkbp:discoveredBy gptkb:Irwin_Fridovich
gptkb:Joe_M._McCord
gptkbp:discoveredIn 1969
gptkbp:EC_number 1.15.1.1
gptkbp:Entrez_Gene_ID 6647 (human)
gptkbp:family gptkb:superoxide_dismutase_family
gptkbp:function catalyzes dismutation of superoxide radicals
gptkbp:gene gptkb:SOD1
gptkbp:GO gptkb:GO:0004784
https://www.w3.org/2000/01/rdf-schema#label Cu,Zn-superoxide dismutase
gptkbp:inhibitedBy gptkb:diethyldithiocarbamate
cyanide
gptkbp:locatedOnChromosome gptkb:21q22.11_(human)
gptkbp:location gptkb:cytoplasm
gptkb:mitochondrial_intermembrane_space
gptkbp:molecularWeight 32 kDa
gptkbp:mutationAssociatedWith linked to familial ALS
gptkbp:OMIM 147450
gptkbp:organism gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:PDB gptkb:1HL5
gptkbp:product hydrogen peroxide
oxygen
gptkbp:structure homodimer
gptkbp:substrate gptkb:superoxide_anion
gptkbp:UniProtID gptkb:P00441
gptkbp:bfsParent gptkb:superoxide_dismutase_[Cu-Zn]
gptkbp:bfsLayer 6