Complex IV of respiratory chain

URI: https://gptkb.org/entity/Complex_IV_of_respiratory_chain
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs cytochrome c oxidase
gptkbp:cofactor gptkb:heme_a3
gptkb:heme_a
copper A
copper B
gptkbp:compatibleWith prokaryotes (as this specific complex)
gptkbp:component electron transport chain
respiratory chain
gptkbp:discoveredBy gptkb:David_Keilin
gptkbp:EC_number 1.9.3.1
gptkbp:encodedBy gptkb:mitochondrial_DNA
nuclear DNA
gptkbp:function catalyzes reduction of oxygen to water
transfers electrons from cytochrome c to oxygen
gptkbp:GO_term gptkb:GO:0004129
https://www.w3.org/2000/01/rdf-schema#label Complex IV of respiratory chain
gptkbp:inhibitedBy carbon monoxide
azide
cyanide
gptkbp:locatedIn inner mitochondrial membrane
gptkbp:molecularWeight ~200 kDa
gptkbp:mutationAssociatedWith mitochondrial diseases
gptkbp:numberOfSubunits 13
gptkbp:PDB 1OCC
gptkbp:presentIn eukaryotes
gptkbp:requires aerobic respiration
gptkbp:role ATP synthesis
proton gradient formation
gptkbp:subunit gptkb:COX1
gptkb:COX2
gptkb:COX3
gptkbp:bfsParent gptkb:Cytochrome_c_oxidase_polypeptide_I
gptkbp:bfsLayer 7