|
gptkbp:instanceOf
|
gptkb:antibiotic
cephalosporin
|
|
gptkbp:ATCCode
|
J01DD01
|
|
gptkbp:brand
|
gptkb:Claforan
|
|
gptkbp:CASNumber
|
63527-52-6
|
|
gptkbp:chemicalClass
|
gptkb:antibiotic
|
|
gptkbp:contraindication
|
hypersensitivity to cephalosporins
|
|
gptkbp:discoveredBy
|
gptkb:Hoechst_AG
|
|
gptkbp:eliminationHalfLife
|
1 hour
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:hasMolecularFormula
|
C16H17N5O7S2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cefotaxime
|
|
gptkbp:introducedIn
|
1980
|
|
gptkbp:KEGGID
|
D00255
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial cell wall synthesis
|
|
gptkbp:meltingPoint
|
163-164°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notEffectiveAgainst
|
gptkb:Enterococcus
gptkb:methicillin-resistant_Staphylococcus_aureus_(MRSA)
Pseudomonas aeruginosa (variable)
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:proteinBinding
|
30-50%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1092
441203
389430
DB00493
|
|
gptkbp:routeOfAdministration
|
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
rash
allergic reactions
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:synonym
|
gptkb:Cefotaxima
gptkb:Cefotaximum
|
|
gptkbp:treatment
|
gptkb:pneumonia
meningitis
sepsis
bacterial endocarditis
urinary tract infections
gonorrhea
intra-abdominal infections
skin and soft tissue infections
bone and joint infections
|
|
gptkbp:UNII
|
JGS2G8S351
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:CTX
|
|
gptkbp:bfsLayer
|
6
|