|
gptkbp:instanceOf
|
gptkb:antibiotic
|
|
gptkbp:administeredBy
|
oral
intramuscular
intravenous
|
|
gptkbp:alternativeName
|
cephalosporin_antibiotic
third-generation_cephalosporin
|
|
gptkbp:ATCCode
|
J01D
|
|
gptkbp:chemicalFormula
|
contains beta-lactam ring
|
|
gptkbp:class
|
cephalosporin
fifth-generation cephalosporin
first-generation cephalosporin
fourth-generation cephalosporin
second-generation cephalosporin
|
|
gptkbp:contraindication
|
penicillin allergy
|
|
gptkbp:discoveredBy
|
gptkb:Giuseppe_Brotzu
|
|
gptkbp:discoveredIn
|
1945
|
|
gptkbp:example
|
gptkb:cefepime
gptkb:ceftaroline
gptkb:ceftriaxone
gptkb:cephalexin
cefuroxime
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial cell wall synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notEffectiveAgainst
|
gptkb:Enterococcus
atypical bacteria
methicillin-resistant Staphylococcus aureus (except some fifth-generation)
|
|
gptkbp:origin
|
gptkb:Cephalosporium_acremonium
|
|
gptkbp:pregnancyCategory
|
B (varies by drug)
|
|
gptkbp:relatedTo
|
gptkb:antibiotic
|
|
gptkbp:resistantTo
|
beta-lactamase production
|
|
gptkbp:riskFactor
|
gptkb:Clostridioides_difficile_infection
|
|
gptkbp:sideEffect
|
nausea
diarrhea
allergic reaction
rash
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:usedIn
|
gptkb:pneumonia
meningitis
sepsis
urinary tract infection
skin infection
bone and joint infection
|
|
gptkbp:bfsParent
|
gptkb:cephalosporins
gptkb:ceftriaxone
gptkb:Zerbaxa
gptkb:Ceftriaxone
|
|
gptkbp:bfsLayer
|
6
|