|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
Caveolin-1 alpha
Caveolin-1 beta
|
|
gptkbp:associatedWith
|
caveolae formation
|
|
gptkbp:discoveredBy
|
1992
|
|
gptkbp:domain
|
caveolin domain
|
|
gptkbp:encodedBy
|
CAV1 gene
|
|
gptkbp:expressedIn
|
endothelial cells
fibroblasts
muscle cells
adipocytes
|
|
gptkbp:foundIn
|
gptkb:plasma_membrane
caveolae
|
|
gptkbp:function
|
cholesterol homeostasis
endocytosis
scaffolding protein
regulation of signal transduction
|
|
gptkbp:gene
|
gptkb:CAV1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Caveolin-1
|
|
gptkbp:inhibitedBy
|
endothelial nitric oxide synthase activity
|
|
gptkbp:interactsWith
|
gptkb:Src_family_kinases
gptkb:endothelial_nitric_oxide_synthase
G-protein coupled receptors
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:cardiovascular_disease
pulmonary fibrosis
insulin resistance
lipodystrophy
|
|
gptkbp:locatedOnChromosome
|
7q31.1
|
|
gptkbp:molecularWeight
|
~21-24 kDa
|
|
gptkbp:mutationAssociatedWith
|
congenital generalized lipodystrophy type 3
|
|
gptkbp:orthologInMouse
|
Cav1
|
|
gptkbp:PDB
|
1U7F
|
|
gptkbp:phosphorylates
|
tyrosine-14
|
|
gptkbp:regulates
|
apoptosis
cell migration
cellular proliferation
vesicular trafficking
|
|
gptkbp:reviewedBy
|
gptkb:Journal_of_Cell_Science
gptkb:Nature_Reviews_Molecular_Cell_Biology
|
|
gptkbp:structure
|
integral membrane protein
|
|
gptkbp:subunit
|
caveolae coat complex
|
|
gptkbp:UniProtID
|
Q03135
|
|
gptkbp:bfsParent
|
gptkb:CAV1
gptkb:Caveolae-associated_protein_2
gptkb:Cavin-2
|
|
gptkbp:bfsLayer
|
7
|