|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CT-1
cardiac hypertrophy factor
|
|
gptkbp:associatedWith
|
heart failure
inflammatory diseases
cardiac hypertrophy
|
|
gptkbp:biologicalProcess
|
cell proliferation
cell survival
apoptosis regulation
|
|
gptkbp:clinical_biomarker
|
heart failure
|
|
gptkbp:discoveredBy
|
1995
|
|
gptkbp:Entrez_Gene_ID
|
1481
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cytokine activity
cardiac hypertrophy induction
|
|
gptkbp:gene
|
gptkb:CTF1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cardiotrophin-1
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:OMIM
|
600235
|
|
gptkbp:orthologInMouse
|
Ctf1
|
|
gptkbp:PDB
|
1J7V
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:producedBy
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:testis
gptkb:cardiac_myocytes
liver
|
|
gptkbp:proteinFamily
|
gptkb:interleukin-6_family
|
|
gptkbp:recipient
|
gp130/LIFRĪ² receptor complex
|
|
gptkbp:secreted_protein
|
yes
|
|
gptkbp:signal_transduction_pathway
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
|
|
gptkbp:structure
|
contains four-helix bundle
|
|
gptkbp:therapeutic_target
|
cardiovascular diseases
|
|
gptkbp:UniProtID
|
gptkb:Q16619
|
|
gptkbp:bfsParent
|
gptkb:CT-1
|
|
gptkbp:bfsLayer
|
7
|