|
gptkbp:instanceOf
|
gptkb:antibiotic
|
|
gptkbp:administeredBy
|
intravenous injection
|
|
gptkbp:ATCCode
|
J01DH
|
|
gptkbp:chemicalFormula
|
beta-lactam ring with a carbon atom at position 1
|
|
gptkbp:concerns
|
gptkb:carbapenem-resistant_Enterobacteriaceae
|
|
gptkbp:contraindication
|
patients with carbapenem allergy
|
|
gptkbp:developedBy
|
Merck & Co. (imipenem)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:drugClass
|
antibacterial
|
|
gptkbp:effect
|
Gram-negative bacteria
Gram-positive bacteria
anaerobic bacteria
|
|
gptkbp:eliminatedIn
|
renal excretion
|
|
gptkbp:example
|
gptkb:meropenem
gptkb:ertapenem
gptkb:imipenem
doripenem
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Carbapenems
|
|
gptkbp:mechanismOfAction
|
inhibit bacterial cell wall synthesis
|
|
gptkbp:notEffectiveAgainst
|
carbapenemase-producing bacteria
|
|
gptkbp:resistantTo
|
most beta-lactamases
|
|
gptkbp:sideEffect
|
seizures
allergic reactions
gastrointestinal upset
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:subclassOf
|
gptkb:beta-lactam_antibiotics
|
|
gptkbp:usedFor
|
hospital-acquired infections
severe bacterial infections
|
|
gptkbp:usedIn
|
intensive care units
|
|
gptkbp:WHOStatus
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:bfsParent
|
gptkb:J01DH03
|
|
gptkbp:bfsLayer
|
6
|